Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori.
Journal: 2006/February - World Journal of Gastroenterology
ISSN: 1007-9327
PUBMED: 16437723
Abstract:
OBJECTIVE
To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori (H. pylori).
METHODS
Twenty-five plants were boiled in water to produce aqueous extracts that simulate the effect of cooking. The bactericidal activity of the extracts was assessed by a standard kill-curve with seven strains of H. pylori. The anti-adhesive property was assessed by the inhibition of binding of four strains of FITC-labeled H. pylori to stomach sections.
RESULTS
Of all the plants tested, eight plants, including Bengal quince, nightshade, garlic, dill, black pepper, coriander, fenugreek and black tea, were found to have no bactericidal effect on any of the isolates. Columbo weed, long pepper, parsley, tarragon, nutmeg, yellow-berried nightshade, threadstem carpetweed, sage and cinnamon had bactericidal activities against H. pylori, but total inhibition of growth was not achieved in this study. Among the plants that killed H. pylori, turmeric was the most efficient, followed by cumin, ginger, chilli, borage, black caraway, oregano and liquorice. Moreover, extracts of turmeric, borage and parsley were able to inhibit the adhesion of H. pylori strains to the stomach sections.
CONCLUSIONS
Several plants that were tested in our study had bactericidal and/or anti-adhesive effects on H. pylori. Ingestion of the plants with anti-adhesive properties could therefore provide a potent alternative therapy for H. pylori infection, which overcomes the problem of resistance associated with current antibiotic treatment.
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World J Gastroenterol 11(47): 7499-7507

Bactericidal and anti-adhesive properties of culinary and medicinal plants against <em>Helicobacter pylori</em>

Rachel O’Mahony, Huda Al-Khtheeri, John Holton, Centre for Infectious Diseases and International Health, Royal Free and University College London Medical School, London, United Kingdom
Deepaka Weerasekera, Department of Surgery, University of Sri Jayewardenapura, Colombo, Sri Lanka
Neluka Fernando, Department of Microbiology, University of Sri Jayewardenapura, Colombo, Sri Lanka
Dino Vaira, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Christelle Basset, INSERM 0114, Physiopathologie des Maladies Inflammatoires Intestinales, CHU Lille, France
Author contributions: All authors contributed equally to the work.

Correspondence to: Rachel O’Mahony, Centre for Infectious Diseases and International Health, Royal Free and University College London Medical School, Windeyer Building, 46 Cleveland Street, London, W1P 6DB, United Kingdom.

Telephone: +44-20-76799485

Rachel O’Mahony, Huda Al-Khtheeri, John Holton, Centre for Infectious Diseases and International Health, Royal Free and University College London Medical School, London, United Kingdom
Deepaka Weerasekera, Department of Surgery, University of Sri Jayewardenapura, Colombo, Sri Lanka
Neluka Fernando, Department of Microbiology, University of Sri Jayewardenapura, Colombo, Sri Lanka
Dino Vaira, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Christelle Basset, INSERM 0114, Physiopathologie des Maladies Inflammatoires Intestinales, CHU Lille, France
Author contributions: All authors contributed equally to the work.

Correspondence to: Rachel O’Mahony, Centre for Infectious Diseases and International Health, Royal Free and University College London Medical School, Windeyer Building, 46 Cleveland Street, London, W1P 6DB, United Kingdom.

Telephone: +44-20-76799485

Received 2005 Mar 2; Revised 2005 Apr 23; Accepted 2005 Apr 28.

Abstract

AIM: To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori (H pylori).

METHODS: Twenty-five plants were boiled in water to produce aqueous extracts that simulate the effect of cooking. The bactericidal activity of the extracts was assessed by a standard kill-curve with seven strains of H pylori. The anti-adhesive property was assessed by the inhibition of binding of four strains of FITC-labeled H pylori to stomach sections.

RESULTS: Of all the plants tested, eight plants, including Bengal quince, nightshade, garlic, dill, black pepper, coriander, fenugreek and black tea, were found to have no bactericidal effect on any of the isolates. Columbo weed, long pepper, parsley, tarragon, nutmeg, yellow-berried nightshade, threadstem carpetweed, sage and cinnamon had bactericidal activities against H pylori, but total inhibition of growth was not achieved in this study. Among the plants that killed H pylori, turmeric was the most efficient, followed by cumin, ginger, chilli, borage, black caraway, oregano and liquorice. Moreover, extracts of turmeric, borage and parsley were able to inhibit the adhesion of H pylori strains to the stomach sections.

CONCLUSION: Several plants that were tested in our study had bactericidal and/or anti-adhesive effects on H pylori. Ingestion of the plants with anti-adhesive properties could therefore provide a potent alternative therapy for H pylori infection, which overcomes the problem of resistance associated with current antibiotic treatment.

Keywords: H pylori, Inhibition, Adhesion, Killing, Plants
Abstract

These plants were bought as both fresh and dried material.

Footnotes

Supported by the European Union on EC contract QLK2-CT-2001-01216 (ADRI)

Science Editor Kumar M Language Editor Elsevier HK

Footnotes

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